Dominant DNA Motion

Minor groove view of ensemble average structures for TATA-variants over 2.4 ns DNA/ion/water simulations.(global helical axes displayed) Full range of motion along first principal componentWT & T26: Mgroove bendingA29: mgroove bending (For detailed information, see the article "Dynamic Simulations of 13 TATA Variants Refine Kinetic Hypotheses on Sequence/Activity Relationships", X. Qian, D. Strahs, and T. Schlick, J. Mol. biol., In Press 2001).